SPDL1 and PPP1R18

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SPDL1	PPP1R18
Description		spindle apparatus coiled-coil protein 1	protein phosphatase 1 regulatory subunit 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Condensed Chromosome Outer Kinetochore Cell Nucleus Microtubule Organizing Center Cytosol	Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding Enzyme Binding Kinetochore Binding	Actin Binding Protein Binding Phosphatase Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Protein Localization To Kinetochore Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Lung cancer ( 28604730)
Interacting Genes		10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45	37 interacting genes: CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 DES FAM9B FSD2 GOLGA2 HOMER3 KASH5 KCTD9 KRT13 KRT15 KRT19 KRT31 KRT40 LZTS2 MID2 MTUS2 NEFL PDE4DIP PPP1CA PPP1CC SPDL1 STX11 TCF4 TEX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TRIM69 TSGA10 VPS52
Entrez ID		54908	170954
HPRD ID		08623	11172
Ensembl ID		ENSG00000040275	ENSG00000146112
Uniprot IDs		Q96EA4	A0A024RCJ8 Q6NYC8
PDB IDs
Enriched GO Terms of Interacting Partners?
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