FBXL12 and ALDH3A1

Number of citations of the paper that reports this interaction (PubMedID 26124079)
5

Data Source:
BioGRID (enzymatic study)

		FBXL12	ALDH3A1
Description		F-box and leucine rich repeat protein 12	aldehyde dehydrogenase 3 family member A1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol SCF Ubiquitin Ligase Complex	Extracellular Space Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Benzaldehyde Dehydrogenase (NAD+) Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Cell Cycle	Response To Hypoxia Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Drug Response To Glucocorticoid Response To CAMP Oxidation-reduction Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Phase I - Functionalization of compounds
Drugs			NADH
Diseases
GWAS		Pursuit maintenance gain ( 29064472)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576 29875488) Intraocular pressure ( 29617998) Refractive astigmatism ( 30306274)
Interacting Genes		22 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FXYD3 LNX1 MARCHF2 MAST1 PSEN1 PSEN2 PSME3 RNF32 SHFL SMAD1 TGFBR1 UBE2D3 ZNF44 ZNF562 ZNF823	4 interacting genes: CYHR1 FBXL12 POT1 SRF
Entrez ID		54850	218
HPRD ID		12363	00004
Ensembl ID		ENSG00000127452	ENSG00000108602
Uniprot IDs		Q9NXK8	I3L3I9 P30838 Q6PKA6
PDB IDs			3SZA 3SZB 4H80 4L1O 4L2O
Enriched GO Terms of Interacting Partners?
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