ALDH3A1 and FBXL12

Number of citations of the paper that reports this interaction (PubMedID 26124079)
5

Data Source:
BioGRID (enzymatic study)

		ALDH3A1	FBXL12
Description		aldehyde dehydrogenase 3 family member A1	F-box and leucine rich repeat protein 12
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Membrane	Nucleus Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Benzaldehyde Dehydrogenase (NAD+) Activity	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Response To Hypoxia Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Drug Response To Glucocorticoid Response To CAMP Oxidation-reduction Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Cell Cycle
Pathways		Phase I - Functionalization of compounds	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		NADH
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576 29875488) Intraocular pressure ( 29617998) Refractive astigmatism ( 30306274)	Pursuit maintenance gain ( 29064472)
Interacting Genes		4 interacting genes: CYHR1 FBXL12 POT1 SRF	22 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FXYD3 LNX1 MARCHF2 MAST1 PSEN1 PSEN2 PSME3 RNF32 SHFL SMAD1 TGFBR1 UBE2D3 ZNF44 ZNF562 ZNF823
Entrez ID		218	54850
HPRD ID		00004	12363
Ensembl ID		ENSG00000108602	ENSG00000127452
Uniprot IDs		I3L3I9 P30838 Q6PKA6	Q9NXK8
PDB IDs		3SZA 3SZB 4H80 4L1O 4L2O
Enriched GO Terms of Interacting Partners?
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