ZCCHC10 and PTPN3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ZCCHC10	PTPN3
Description		zinc finger CCHC-type containing 10	protein tyrosine phosphatase non-receptor type 3
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding
	Biological Process		Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			EGFR downregulation
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin level ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114)
Interacting Genes		50 interacting genes: ARGLU1 BEND7 CEP63 CEP70 COIL CTNNBL1 DAB1 DACH1 DHX8 DPPA2 DZIP3 EEF1A1 ELOA2 EPB41 FAM9B FRA10AC1 IK KCTD6 KPNA3 LNX1 LUC7L2 NUDT14 PCBP1 PIN1 PPIG PRPF3 PRPF38A PRPF40A PRR13 PSME3 PTPN3 RBM39 SART1 SDCBP SDCBP2 SF3B2 SF3B4 SFMBT1 SIAH1 SLU7 SNIP1 SNRPD2 STAC3 STX11 TFCP2 THAP1 TP53 U2AF1 ZBTB14 ZBTB8A	18 interacting genes: ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 NXT2 RPS6KA1 VCP WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10
Entrez ID		54819	5774
HPRD ID		15699	06767
Ensembl ID		ENSG00000155329	ENSG00000070159
Uniprot IDs		B3KVL5 B4DU89 D6R9G7 D6RHC2 G3XAM1 Q8TBK6	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs			2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS
Enriched GO Terms of Interacting Partners?
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