PPP1R12C and MYL2

Number of citations of the paper that reports this interaction (PubMedID 11399775)
51

Data Source:
HPRD (in vivo, in vitro)

		PPP1R12C	MYL2
Description		protein phosphatase 1 regulatory subunit 12C	myosin light chain 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding
	Biological Process	Signal Transduction Negative Regulation Of Catalytic Activity	Regulation Of The Force Of Heart Contraction Regulation Of Striated Muscle Contraction Heart Development Post-embryonic Development Muscle Filament Sliding Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Fiber Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Positive Regulation Of The Force Of Heart Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS			Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Alcohol consumption (max-drinks) ( 29460428) Body mass index ( 24861553) Coffee consumption ( 29367735) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) Gout ( 25646370) HDL cholesterol ( 21909109) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 30718733) Metabolic syndrome ( 25705158) Metabolic syndrome (multivariate analysis) ( 29632305) Neutrophil count ( 29403010) Urate levels ( 31578528) White blood cell count ( 29403010)
Interacting Genes		13 interacting genes: ATXN7 C1orf109 CACNA1A CDC42BPA IL16 MPRIP MYL2 NOD2 PAFAH1B2 PPP1CB RBM17 SMAD3 TSFM	11 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C TRIM63 USP6 ZNF529
Entrez ID		54776	4633
HPRD ID		11452	01181
Ensembl ID		ENSG00000125503	ENSG00000111245
Uniprot IDs		Q9BZL4	P10916 Q6IB42
PDB IDs			5TBY
Enriched GO Terms of Interacting Partners?
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