PDP1 and CBFA2T2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PDP1	CBFA2T2
Description		pyruvate dehyrogenase phosphatase catalytic subunit 1	CBFA2/RUNX1 partner transcriptional co-repressor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus
	Molecular Function	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Protein Binding Metal Ion Binding	DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Peptidyl-threonine Dephosphorylation Positive Regulation Of Pyruvate Dehydrogenase Activity	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Intestinal Epithelial Cell Differentiation
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex
Drugs
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Height ( 28552196)
Interacting Genes		8 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 PDHA1 PLEKHF2 PRKCD SIRT3	22 interacting genes: APP ATN1 ATXN1L CBFA2T3 CBFB FBXL19 GTF2E1 ID3 LBP MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 NTAQ1 PDP1 RERE RUNX1 SIN3A TAL2 TCP1 ZNF652
Entrez ID		54704	9139
HPRD ID		16185	04721
Ensembl ID		ENSG00000164951	ENSG00000078699
Uniprot IDs		A0A024R9C0 Q6P1N1 Q9P0J1	O43439
PDB IDs
Enriched GO Terms of Interacting Partners?
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