PPARD and HSP90AA1

Number of citations of the paper that reports this interaction (PubMedID 22939624)
275

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PPARD	HSP90AA1
Description		peroxisome proliferator activated receptor delta	heat shock protein 90 alpha family class A member 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane Protein-containing Complex Secretory Granule Lumen Melanosome Neuronal Cell Body Lysosomal Lumen Myelin Sheath Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Fatty Acid Binding Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Lipid Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity NF-kappaB Binding Linoleic Acid Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	RNA Binding Protein Binding ATP Binding ATPase Activity MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Tau Protein Binding GTPase Binding Unfolded Protein Binding DNA Polymerase Binding Scaffold Protein Binding Disordered Domain Specific Binding Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Vitamin A Metabolic Process Apoptotic Process Multicellular Organism Development Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process MRNA Transcription Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Transport Regulation Of Lipid Metabolic Process Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Response To Nutrient Levels Positive Regulation Of Insulin Secretion Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Response To Lipid Wound Healing Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Regeneration Keratinocyte Proliferation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Adipose Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Lipid Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Blood Vessel Diameter Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Glucose Transmembrane Transport Positive Regulation Of Myoblast Proliferation	G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Protein Folding Mitochondrial Transport Receptor-mediated Endocytosis Response To Unfolded Protein Telomere Maintenance Via Telomerase Response To Heat Response To Cold Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Cytokine-mediated Signaling Pathway Central Nervous System Neuron Axonogenesis Establishment Of Cell Polarity Regulation Of Protein Ubiquitination Positive Regulation Of Protein Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Heat Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway Protein Refolding Regulation Of Protein Complex Assembly Neutrophil Degranulation Protein Unfolding Protein Import Into Mitochondrial Outer Membrane Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Antibiotic Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Protein Stabilization Regulation Of Nitric-oxide Synthase Activity Chaperone-mediated Protein Complex Assembly Cofactor Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Chaperone-mediated Autophagy Ciliary Basal Body-plasma Membrane Docking Regulation Of Cellular Response To Heat Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cellular Protein Localization Telomerase Holoenzyme Complex Assembly
Pathways		Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Nuclear Receptor transcription pathway Signaling by Retinoic Acid	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation vRNP Assembly Regulation of actin dynamics for phagocytic cup formation eNOS activation Regulation of PLK1 Activity at G2/M Transition Scavenging by Class F Receptors Scavenging by Class F Receptors HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase HSF1-dependent transactivation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Sema3A PAK dependent Axon repulsion VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability Uptake and function of diphtheria toxin PIWI-interacting RNA (piRNA) biogenesis Anchoring of the basal body to the plasma membrane Constitutive Signaling by EGFRvIII Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Downregulation of ERBB2 signaling ESR-mediated signaling Extra-nuclear estrogen signaling Estrogen-dependent gene expression Chaperone Mediated Autophagy Constitutive Signaling by Overexpressed ERBB2 Aggrephagy Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		Alpha-Linolenic Acid Icosapent Troglitazone Valproic Acid Treprostinil Rosiglitazone Sulindac Fenofibrate Pioglitazone Bezafibrate Phthalic Acid Heptyl-Beta-D-Glucopyranoside Oleic Acid (11E)-OCTADEC-11-ENOIC ACID Elafibranor KD3010 GW-501516 (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid Indeglitazar {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Clinofibrate Glycerin	Rifabutin Nedocromil 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine Geldanamycin 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine Quercetin 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE Tanespimycin SNX-5422 N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE Copper Alvespimycin
Diseases
GWAS		Cataracts in type 2 diabetes ( 23137000) Gout ( 22179738) Heel bone mineral density ( 30598549) Height ( 21998595 28552196) Lymphocyte counts ( 27863252) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		40 interacting genes: BCL6 CEP350 DUT EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NRIP1 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 PSMC5 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC STAT3 TNP1	153 interacting genes: AHR AHSA1 AHSA2P AIP AIPL1 AKT1 AKT2 APAF1 APOB AR ARNTL ASGR1 BIRC5 BRMS1 CACYBP CALM1 CDC37 CDC37L1 CDK4 CDK5R1 CDKN2A CERS2 CFTR CHEK1 CHUK CKS1B CKS2 CRNKL1 CSNK2A1 CSNK2A2 DAP3 DNAJC7 EGFR EGLN1 EIF2AK1 EIF2AK2 EIF2AK3 EIF2S1 EPAS1 EPRS1 ERBB2 ERN1 ESR1 ESRRB FAM162A FANCA FANCC FKBP1A FKBP4 FKBP5 FKBP6 FLCN FNIP1 FYN GNA12 GSK3B GUCY1B1 GZMA HDAC6 HIF1A HIF3A HSF1 HSPA8 HTT IKBKB IKBKE IKBKG IP6K2 IRAK1 IRF3 JUN KDR KEAP1 LCK LSM1 MAP3K14 MAP3K3 MAPK1 MAPT MIS12 MMP2 MS4A2 MTRNR2L1 MUC1 MYC MYOD1 NDRG1 NOS1 NOS3 NPAS2 NR2C2 NR3C1 NR3C2 NSL1 PABPN1 PAK1 PDPK1 PIM1 PMF1 PPARA PPARD PPID PPIL2 PPP5C PRKACA PRKCA PRKCD PRKDC PTGDS PTGES3 PTPRF RAD51 RAF1 RHOBTB2 RIPK1 RPAP3 RPS3 RPS3A RUNX1T1 SERPINB5 SGTA SIM1 SKP1 SLC2A4 SLC34A1 SMYD2 SMYD3 SNCA SRC ST13 STARD13 STAT3 STIP1 STUB1 SUGT1 SVIL TBK1 TERT TJP1 TNFRSF1A TOMM34 TOMM40 TOMM70 TP53 TTK TTR UBE2N UCHL1 UNC45A USP13 USP19 USP50 WASL
Entrez ID		5467	3320
HPRD ID		02679	00777
Ensembl ID		ENSG00000112033	ENSG00000080824
Uniprot IDs		A0A024RCW6 F1D8S7 Q03181	K9JA46 P07900 Q86SX1
PDB IDs		1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM 5U3Q 5U3R 5U3S 5U3T 5U3U 5U3V 5U3W 5U3X 5U3Y 5U3Z 5U40 5U41 5U42 5U43 5U44 5U45 5U46 5XMX 5Y7X 5ZXI 6A6P	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5NYH 5NYI 5OCI 5OD7 5ODX 5T21 5VYY 5XQD 5XQE 5XR5 5XR9 5XRB 5XRD 5XRE 5ZR3 6B99 6B9A 6CEO 6CYG 6CYH 6EI5 6EL5 6ELN 6ELO 6ELP 6EY8 6EY9 6EYA 6EYB 6F1N 6FCJ 6FDP 6GP4 6GP8 6GPF 6GPH 6GPO 6GPP 6GPR 6GPT 6GPW 6GPY 6GQ6 6GQR 6GQS 6GQU 6GR1 6GR3 6GR4 6GR5 6HHR 6N8X 6OLX
Enriched GO Terms of Interacting Partners?
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