PPARD and SPEN

Number of citations of the paper that reports this interaction (PubMedID 11867749)
95

Data Source:
HPRD (in vivo)

		PPARD	SPEN
Description		peroxisome proliferator activated receptor delta	spen family transcriptional repressor
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex	Nucleoplasm Transcriptional Repressor Complex Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Fatty Acid Binding Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Lipid Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity NF-kappaB Binding Linoleic Acid Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Vitamin A Metabolic Process Apoptotic Process Multicellular Organism Development Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process MRNA Transcription Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Cholesterol Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Transport Regulation Of Lipid Metabolic Process Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Response To Nutrient Levels Positive Regulation Of Insulin Secretion Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Response To Lipid Wound Healing Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Skeletal Muscle Tissue Regeneration Keratinocyte Proliferation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Adipose Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Lipid Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Blood Vessel Diameter Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Glucose Transmembrane Transport Positive Regulation Of Myoblast Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis
Pathways		Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Nuclear Receptor transcription pathway Signaling by Retinoic Acid
Drugs		Alpha-Linolenic Acid Icosapent Troglitazone Valproic Acid Treprostinil Rosiglitazone Sulindac Fenofibrate Pioglitazone Bezafibrate Phthalic Acid Heptyl-Beta-D-Glucopyranoside Oleic Acid (11E)-OCTADEC-11-ENOIC ACID Elafibranor KD3010 GW-501516 (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid Indeglitazar {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Clinofibrate Glycerin
Diseases
GWAS		Cataracts in type 2 diabetes ( 23137000) Gout ( 22179738) Heel bone mineral density ( 30598549) Height ( 21998595 28552196) Lymphocyte counts ( 27863252) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266)	Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591)
Interacting Genes		40 interacting genes: BCL6 CEP350 DUT EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NRIP1 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 PSMC5 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC STAT3 TNP1	22 interacting genes: ATXN1 CLK1 CTBP1 DLX5 HDAC1 HDAC2 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6
Entrez ID		5467	23013
HPRD ID		02679	10230
Ensembl ID		ENSG00000112033	ENSG00000065526
Uniprot IDs		A0A024RCW6 F1D8S7 Q03181	Q96T58
PDB IDs		1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM 5U3Q 5U3R 5U3S 5U3T 5U3U 5U3V 5U3W 5U3X 5U3Y 5U3Z 5U40 5U41 5U42 5U43 5U44 5U45 5U46 5XMX 5Y7X 5ZXI 6A6P	1OW1 2RT5 4P6Q
Enriched GO Terms of Interacting Partners?
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