POU4F1 and RIT2

Number of citations of the paper that reports this interaction (PubMedID 12934100)
4

Data Source:
HPRD (two hybrid, in vitro)

		POU4F1	RIT2
Description		POU class 4 homeobox 1	Ras like without CAAX 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Neuron Projection RNA Polymerase II Transcription Factor Complex	Cell Nucleus Cytoplasm Plasma Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Single-stranded DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Sequence-specific DNA Binding GTPase Binding	Chromatin Binding GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding Semaphorin Receptor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Ventricular Compact Myocardium Morphogenesis Axonogenesis Synapse Assembly Mesoderm Development Heart Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration In Hindbrain Trigeminal Nerve Development Central Nervous System Neuron Differentiation Habenula Development Cell Differentiation Neuron Projection Development Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Sensory System Development Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Regulation Of DNA-binding Transcription Factor Activity Proprioception Involved In Equilibrioception Innervation Positive Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription Elongation By RNA Polymerase I	MAPK Cascade Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling
Pathways		Regulation of TP53 Activity through Association with Co-factors	Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)	Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Acute lymphoblastic leukemia (childhood) ( 23007406) Adverse response to drug ( 30420678) Alcohol consumption (drinks per week) ( 30679032) Autism spectrum disorder ( 26314684) Body mass index ( 28552196 26426971 28892062) Cognitive performance ( 19734545) Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Parkinson's disease ( 22451204 25064009 27182965 21738487) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (PAL4Q3) ( 24024966) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		4 interacting genes: ESR1 EWSR1 NDFIP2 RIT2	12 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RLF SOS1 SRPK2
Entrez ID		5457	6014
HPRD ID		03379	15253
Ensembl ID		ENSG00000152192	ENSG00000152214
Uniprot IDs		Q01851	Q99578
PDB IDs
Enriched GO Terms of Interacting Partners?
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