RIT2 and RALGDS

Number of citations of the paper that reports this interaction (PubMedID 10545207)
24

Data Source:
HPRD (two hybrid)

		RIT2	RALGDS
Description		Ras like without CAAX 2	ral guanine nucleotide dissociation stimulator
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Plasma Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree	Nucleus Cytosol Brush Border
	Molecular Function	Chromatin Binding GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding Semaphorin Receptor Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	MAPK Cascade Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling	Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Signalling to p38 via RIT and RIN	p38MAPK events p38MAPK events
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Acute lymphoblastic leukemia (childhood) ( 23007406) Adverse response to drug ( 30420678) Alcohol consumption (drinks per week) ( 30679032) Autism spectrum disorder ( 26314684) Body mass index ( 28552196 26426971 28892062) Cognitive performance ( 19734545) Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Parkinson's disease ( 22451204 25064009 27182965 21738487) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (PAL4Q3) ( 24024966) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference ( 25673412) Weight ( 28552196)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		12 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RLF SOS1 SRPK2	23 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 HRAS KRAS LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		6014	5900
HPRD ID		15253	03371
Ensembl ID		ENSG00000152214	ENSG00000160271
Uniprot IDs		Q99578	Q12967 Q8N4Y1
PDB IDs			1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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