CYCS and VDAC2

Number of citations of the paper that reports this interaction (PubMedID 9615439)
42

Data Source:
HPRD (in vivo)

		CYCS	VDAC2
Description		cytochrome c, somatic	voltage dependent anion channel 2
Image			No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respiratory Chain	Acrosomal Vesicle Nucleus Mitochondrion Mitochondrial Outer Membrane Synaptic Vesicle Mitochondrial Nucleoid Pore Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity Metal Ion Binding	Nucleotide Binding Protein Binding Voltage-gated Anion Channel Activity Porin Activity
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Protein Dephosphorylation Apoptotic Process Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Response To Oxidative Stress Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration	Anion Transport Binding Of Sperm To Zona Pellucida Inorganic Anion Transport Negative Regulation Of Protein Polymerization Anion Transmembrane Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity	Ub-specific processing proteases Mitochondrial calcium ion transport
Drugs		Minocycline Protoporphyrin Ix Containing Co Heme C Imidazole Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C	Aluminium monostearate PRLX 93936
Diseases		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		21 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	8 interacting genes: ADRB2 APP BAK1 CYCS ECT2 HK1 NEDD4L RPS3A
Entrez ID		54205	7417
HPRD ID		00479	01904
Ensembl ID		ENSG00000172115	ENSG00000165637
Uniprot IDs		G4XXL9 P99999	A0A024QZT0 B4DKM5 P45880
PDB IDs		1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ
Enriched GO Terms of Interacting Partners?
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