CYCS and CYB5R3

Number of citations of the paper that reports this interaction (PubMedID 4403130)
22

Data Source:
HPRD (in vitro)

		CYCS	CYB5R3
Description		cytochrome c, somatic	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respiratory Chain	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity Metal Ion Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding NAD Binding FAD Binding
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Protein Dephosphorylation Apoptotic Process Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Response To Oxidative Stress Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration	Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Blood Circulation L-ascorbic Acid Metabolic Process Neutrophil Degranulation Oxidation-reduction Process
Pathways		Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		Minocycline Protoporphyrin Ix Containing Co Heme C Imidazole Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C	NADH Flavin adenine dinucleotide Copper
Diseases		Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)	Methemoglobinemia
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)	Initial pursuit acceleration ( 29064472)
Interacting Genes		21 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	11 interacting genes: ARSA CYB5A CYCS GAS1 HBG2 L3MBTL2 RPS6KB1 SBF1 SPP1 TUBGCP6 XPNPEP3
Entrez ID		54205	1727
HPRD ID		00479	08942
Ensembl ID		ENSG00000172115	ENSG00000100243
Uniprot IDs		G4XXL9 P99999	P00387
PDB IDs		1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ	1M91 1UMK
Enriched GO Terms of Interacting Partners?
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