PLOD2 and WWTR1

		PLOD2	WWTR1
Description		procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	WW domain containing transcription regulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Body
	Molecular Function	Iron Ion Binding Procollagen-lysine 5-dioxygenase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Response To Hypoxia Cellular Protein Modification Process Protein O-linked Glycosylation Peptidyl-lysine Hydroxylation Hydroxylysine Biosynthetic Process Oxidation-reduction Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Collagen biosynthesis and modifying enzymes	Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Vitamin C
Diseases		Bruck syndrome
GWAS		Height ( 31562340) Obesity-related traits ( 23251661) Squamous cell lung carcinoma ( 28604730) Zinc levels ( 26025379)	Height ( 31562340) Preeclampsia ( 23551011)
Interacting Genes		6 interacting genes: CENPF CLSTN2 LITAF LYPLA1 NUCB1 WWTR1	17 interacting genes: DAPK1 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PLOD2 PPP1CA RUNX1 SLC9A3R2 SUMO3 TEAD3 TEAD4 WBP2 YWHAE YWHAG YWHAZ
Entrez ID		5352	25937
HPRD ID		03519	09580
Ensembl ID		ENSG00000152952	ENSG00000018408
Uniprot IDs		O00469	Q9GZV5
PDB IDs			5N5R 5N5T 5N5W 5N75
Enriched GO Terms of Interacting Partners?
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