WWTR1 and PLOD2

		WWTR1	PLOD2
Description		WW domain containing transcription regulator 1	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Body	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	Iron Ion Binding Procollagen-lysine 5-dioxygenase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway	Response To Hypoxia Cellular Protein Modification Process Protein O-linked Glycosylation Peptidyl-lysine Hydroxylation Hydroxylysine Biosynthetic Process Oxidation-reduction Process
Pathways		Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	Collagen biosynthesis and modifying enzymes
Drugs			Vitamin C
Diseases			Bruck syndrome
GWAS		Height ( 31562340) Preeclampsia ( 23551011)	Height ( 31562340) Obesity-related traits ( 23251661) Squamous cell lung carcinoma ( 28604730) Zinc levels ( 26025379)
Interacting Genes		17 interacting genes: DAPK1 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PLOD2 PPP1CA RUNX1 SLC9A3R2 SUMO3 TEAD3 TEAD4 WBP2 YWHAE YWHAG YWHAZ	6 interacting genes: CENPF CLSTN2 LITAF LYPLA1 NUCB1 WWTR1
Entrez ID		25937	5352
HPRD ID		09580	03519
Ensembl ID		ENSG00000018408	ENSG00000152952
Uniprot IDs		Q9GZV5	O00469
PDB IDs		5N5R 5N5T 5N5W 5N75
Enriched GO Terms of Interacting Partners?
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