PLD1 and PIP5K1A

Number of citations of the paper that reports this interaction (PubMedID 11032811)
30

Data Source:
HPRD (in vivo)

		PLD1	PIP5K1A
Description		phospholipase D1	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse	Nucleus Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Neutrophil Degranulation Positive Regulation Of Translation Inositol Lipid-mediated Signaling Cell Motility Regulation Of Synaptic Vesicle Cycle	Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Phosphatidylinositol Phosphorylation Focal Adhesion Assembly Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation	Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Choline LAX-101
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 29274321) Red cell distribution width ( 27863252 28957414)	Body mass index ( 26426971)
Interacting Genes		26 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL	14 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC
Entrez ID		5337	8394
HPRD ID		03855	04470
Ensembl ID		ENSG00000075651	ENSG00000143398
Uniprot IDs		Q13393 Q59EA4	A6PW57 Q99755
PDB IDs
Enriched GO Terms of Interacting Partners?
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