PKD2 and DIAPH1

Number of citations of the paper that reports this interaction (PubMedID 15123714)
43

Data Source:
HPRD (in vivo)

		PKD2	DIAPH1
Description		polycystin 2, transient receptor potential cation channel	diaphanous related formin 1
Image			No pdb structure
GO Annotations	Cellular Component	Polycystin Complex Cell Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Membrane Lamellipodium Cytoplasmic Vesicle Membrane Motile Cilium Filamentous Actin Cation Channel Complex Ciliary Basal Body Basal Cortex Ciliary Membrane Extracellular Exosome Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Mitotic Spindle Non-motile Cilium	Nucleus Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Secretory Granule Membrane Ruffle Membrane Mitotic Spindle Ficolin-1-rich Granule Membrane
	Molecular Function	Signaling Receptor Binding Voltage-gated Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Cation Channel Activity Calcium Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Outward Rectifier Potassium Channel Activity Voltage-gated Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Ion Channel Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding	RNA Binding Actin Binding Signaling Receptor Binding Protein Binding Rho GTPase Binding Ion Channel Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Calcium Ion Transport Cell Cycle Arrest JAK-STAT Cascade Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Proliferation Cytoplasmic Sequestering Of Transcription Factor Cilium Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Protein Tetramerization Protein Homotetramerization Protein Heterotetramerization Centrosome Duplication Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Positive Regulation Of Cell Cycle Arrest Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Inorganic Cation Transmembrane Transport Cell-cell Signaling By Wnt Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Cell Migration Regulation Of Microtubule-based Process Protein Localization To Microtubule Neutrophil Degranulation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytoskeleton Organization Cellular Response To Histamine Regulation Of Cell Motility
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation
Drugs
Diseases		Polycystic kidney disease
GWAS		Coffee consumption (cups per day) ( 25288136) Dental caries ( 23064961) Gout ( 30899057) Hyperuricemia ( 28776340) Serum uric acid levels in response to allopurinol in gout ( 25676789) Uric acid levels ( 29558500)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Mean platelet volume ( 27863252)
Interacting Genes		17 interacting genes: ACTN2 CD2AP DIAPH1 HAX1 KRT40 KRTAP10-3 KRTAP10-8 LMNA MAGEA8 PACS1 PACS2 PKD1 PLSCR1 PTPRG TNNI3 TPM1 TRPC1	16 interacting genes: APBB1 BAIAP2 CDC7 CENPA GAS7 NEDD4 PAX6 PKD2 PRPF40A PTPRF RAC1 RHOA RHOC TCERG1 WBP4 XPO6
Entrez ID		5311	1729
HPRD ID		01437	03670
Ensembl ID		ENSG00000118762	ENSG00000131504
Uniprot IDs		Q13563 Q9UEU6	A0A2R8Y5N1 O60610 Q6URC4
PDB IDs		2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO 5K47 5MKE 5MKF 5T4D 6A70 6D1W 6T9N 6T9O
Enriched GO Terms of Interacting Partners?
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