PIK3R2 and RINT1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PIK3R2	RINT1
Description		phosphoinositide-3-kinase regulatory subunit 2	RAD50 interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytosol Phosphatidylinositol 3-kinase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Dsl1/NZR Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity	Protein Binding
	Biological Process	Cellular Glucose Homeostasis Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Protein Transport Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling	Retrograde Vesicle-mediated Transport, Golgi To ER Cell Cycle Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Pathways		PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Downstream signal transduction Rho GTPase cycle PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants	COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Isoprenaline SF1126
Diseases
GWAS		Mental health study participation (completed survey) ( 31263887)
Interacting Genes		56 interacting genes: APP APPL1 ARRB1 AXL CBL CD28 CRK CRKL CSF1R DYDC1 EGF EGFR ENKUR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GHR GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LMNA LTBP3 MRFAP1L1 PDGFRB PIK3CD RINT1 SEPTIN2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 STAT3 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB	55 interacting genes: ARNT2 BNIP3L C1orf109 CCDC121 CCDC146 CEP57L1 CSPP1 CWF19L2 DCX EPC1 FAM107A FAM110A FAM124B FAM161A FAM81B FAM90A1 FANCG GFI1B GRAP2 HDAC4 HGS LMO2 LSP1P3 MCM7 PCM1 PIK3R2 PIMREG PRPF31 PSTPIP1 RAD50 RB1 RBL1 RBL2 RBM41 RIBC1 RNF6 RSRC2 RTP5 SCNM1 SFR1 SGF29 SH2D4A SMARCB1 SMARCE1 SNW1 SPTBN1 STRN TEX9 TXLNA VPS37C XPNPEP1 ZNF655 ZNF688 ZNF697 ZW10
Entrez ID		5296	60561
HPRD ID		04404	15250
Ensembl ID		ENSG00000105647	ENSG00000135249
Uniprot IDs		O00459	Q6NUQ1
PDB IDs		2KT1 2XS6 3MTT 3O5Z
Enriched GO Terms of Interacting Partners?
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