PIK3C3 and FBXL20

Number of citations of the paper that reports this interaction (PubMedID 25593308)
21

Data Source:
BioGRID (enzymatic study)

		PIK3C3	FBXL20
Description		phosphatidylinositol 3-kinase catalytic subunit type 3	F-box and leucine rich repeat protein 20
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Peroxisome Cytosol Axoneme Membrane Midbody Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome	Cytosol SCF Ubiquitin Ligase Complex Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Autophagosome Assembly Protein Phosphorylation Protein Lipidation Phosphatidylinositol Biosynthetic Process Endocytosis Autophagy Endosome Organization Cell Cycle Macroautophagy Protein Processing Autophagy Of Peroxisome Regulation Of Cytokinesis Toll-like Receptor 9 Signaling Pathway Protein Localization To Phagophore Assembly Site Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Response To Leucine Early Endosome To Late Endosome Transport Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Regulation Of Protein Secretion Cell Division	Protein Polyubiquitination Behavioral Fear Response Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis
Pathways		PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) General risk tolerance (MTAG) ( 30643258) Obese vs. thin ( 30677029) Obesity-related traits ( 23251661) Periodontitis (PAL4Q3) ( 24024966)	Asthma ( 31619474) Coronary artery disease ( 29212778) Creatinine levels ( 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate (creatinine) ( 26831199) Lung function (FVC) ( 30804560) Microalbuminuria ( 31511532) Rapid automised naming of pictures ( 30741946) Ulcerative colitis ( 20228799) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		7 interacting genes: CALM1 CASP8 FBXL20 PIK3R4 PITPNA YWHAG YWHAQ	1 interacting genes: PIK3C3
Entrez ID		5289	84961
HPRD ID		04009	10951
Ensembl ID		ENSG00000078142	ENSG00000108306
Uniprot IDs		A8MYT4 B4DPV9 Q8NEB9	Q96IG2
PDB IDs		3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6I3U
Enriched GO Terms of Interacting Partners?
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