PIK3C3 and PIK3R4

Number of citations of the paper that reports this interaction (PubMedID 8999962)
61

Data Source:
HPRD (in vivo, in vitro)

		PIK3C3	PIK3R4
Description		phosphatidylinositol 3-kinase catalytic subunit type 3	phosphoinositide-3-kinase regulatory subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Endosome Late Endosome Peroxisome Cytosol Axoneme Membrane Midbody Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Autolysosome	Late Endosome Autophagosome Cytosol Axoneme Microtubule Cytoskeleton Membrane Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Intracellular Membrane-bounded Organelle Nucleus-vacuole Junction
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Autophagosome Assembly Protein Phosphorylation Protein Lipidation Phosphatidylinositol Biosynthetic Process Endocytosis Autophagy Endosome Organization Cell Cycle Macroautophagy Protein Processing Autophagy Of Peroxisome Regulation Of Cytokinesis Toll-like Receptor 9 Signaling Pathway Protein Localization To Phagophore Assembly Site Phosphatidylinositol-3-phosphate Biosynthetic Process Cellular Response To Glucose Starvation Response To Leucine Early Endosome To Late Endosome Transport Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Regulation Of Protein Secretion Cell Division	Protein Phosphorylation Protein Targeting To Vacuole Phosphatidylinositol Biosynthetic Process Macroautophagy Autophagy Of Peroxisome Regulation Of Cytokinesis Receptor Catabolic Process Toll-like Receptor 9 Signaling Pathway Cellular Response To Glucose Starvation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Late Endosome To Vacuole Transport
Pathways		PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases	PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases
Drugs		N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) General risk tolerance (MTAG) ( 30643258) Obese vs. thin ( 30677029) Obesity-related traits ( 23251661) Periodontitis (PAL4Q3) ( 24024966)	Abdominal aortic calcification levels ( 31659325)
Interacting Genes		7 interacting genes: CALM1 CASP8 FBXL20 PIK3R4 PITPNA YWHAG YWHAQ	4 interacting genes: MAPRE1 PIK3C3 RACK1 YWHAB
Entrez ID		5289	30849
HPRD ID		04009	04010
Ensembl ID		ENSG00000078142	ENSG00000196455
Uniprot IDs		A8MYT4 B4DPV9 Q8NEB9	Q99570
PDB IDs		3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN 6I3U
Enriched GO Terms of Interacting Partners?
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