SERPINB6 and KLK2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		SERPINB6	KLK2
Description		serpin family B member 6	kallikrein related peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Secretory Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Ficolin-1-rich Granule Membrane	Extracellular Region Secretory Granule Extracellular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity
	Biological Process	Sensory Perception Of Sound Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Cellular Response To Osmotic Stress	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation
Pathways		Neutrophil degranulation Dissolution of Fibrin Clot	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Drotrecogin alfa
Diseases
GWAS		Chronic lymphocytic leukemia ( 26956414)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		6 interacting genes: F10 F2 KLK2 PLAU PLG PROC	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		5269	3817
HPRD ID		01413	01006
Ensembl ID		ENSG00000124570	ENSG00000167751
Uniprot IDs		A0A024QZX3 A0A024QZX5 A0A087X1N8 A0A2R8YD12 P35237	A0A024R4J4 A0A024R4N3 B4DU77 P20151
PDB IDs			4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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