KLK2 and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 9428387)
10

Data Source:
HPRD (in vivo, in vitro)

		KLK2	SERPINA3
Description		kallikrein related peptidase 2	serpin family A member 3
Image
GO Annotations	Cellular Component	Extracellular Region Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Platelet degranulation Neutrophil degranulation
Drugs			Zinc
Diseases
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)	Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)
Interacting Genes		14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	26 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		3817	12
HPRD ID		01006	00120
Ensembl ID		ENSG00000167751	ENSG00000196136
Uniprot IDs		A0A024R4J4 A0A024R4N3 B4DU77 P20151	A0A024R6P0 P01011
PDB IDs		4NFE 4NFF	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE
Enriched GO Terms of Interacting Partners?
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