SERPINB5 and LRRFIP1

Number of citations of the paper that reports this interaction (PubMedID 16049007)
27

Data Source:
BioGRID (two hybrid)

		SERPINB5	LRRFIP1
Description		serpin family B member 5	LRR binding FLII interacting protein 1
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded RNA Binding Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Morphogenesis Of An Epithelium Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type I Interferon Production Negative Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Signaling by cytosolic FGFR1 fusion mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by FGFR1 in disease
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)	Adiposity ( 23505185) Longevity ( 30294719)
Interacting Genes		26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF SMAD4 STK11 TBP TKT UCHL5 XRCC3	6 interacting genes: CEP44 FBXO7 FLII MED4 SERPINB5 SH2D2A
Entrez ID		5268	9208
HPRD ID		01111	04460
Ensembl ID		ENSG00000206075	ENSG00000124831
Uniprot IDs		A0A024R2B6 P36952	A0A0F7NGI8 B4DPC0 Q32MZ4
PDB IDs		1WZ9 1XQG 1XQJ 1XU8	4H22
Enriched GO Terms of Interacting Partners?
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