PHYH and FKBP4

Number of citations of the paper that reports this interaction (PubMedID 10051602)
5

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		PHYH	FKBP4
Description		phytanoyl-CoA 2-hydroxylase	FKBP prolyl isomerase 4
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GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Matrix Cytosol	Nucleoplasm Cytoplasm Mitochondrion Cytosol Microtubule Protein-containing Complex Neuronal Cell Body Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Ferrous Iron Binding Carboxylic Acid Binding L-ascorbic Acid Binding Cofactor Binding Phytanoyl-CoA Dioxygenase Activity	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding ATP Binding GTP Binding FK506 Binding Protein Binding, Bridging Heat Shock Protein Binding Copper-dependent Protein Binding Glucocorticoid Receptor Binding Tau Protein Binding Phosphoprotein Binding
	Biological Process	Fatty Acid Alpha-oxidation 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome Isoprenoid Metabolic Process 2-oxobutyrate Catabolic Process Methyl-branched Fatty Acid Metabolic Process	Protein Peptidyl-prolyl Isomerization Protein Folding Steroid Hormone Receptor Complex Assembly Copper Ion Transport Embryo Implantation Negative Regulation Of Neuron Projection Development Androgen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Protein-containing Complex Localization Male Sex Differentiation Chaperone-mediated Protein Folding Regulation Of Cellular Response To Heat
Pathways		Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase ESR-mediated signaling Estrogen-dependent gene expression
Drugs		Antihemophilic factor, human recombinant Vitamin C
Diseases		Refsum disease; Heredopathia atactica polyneuritiformis
GWAS			FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Quantitative traits ( 19197348)
Interacting Genes		10 interacting genes: ACSL6 APP F8 FAM9B FKBP4 MAGEA11 PEX7 PHYHIP SIRPA TOM1L1	26 interacting genes: ACVR1 AHSA1 ATOX1 CALM1 CSNK2A1 EGFR ESR1 FES FKBP1A GLMN HSF1 HSP90AA1 HSPA4 IRF4 NR3C1 NR3C2 PHYH PTPN2 S100A1 S100A2 S100A6 SH3BP4 SMURF2 SNCA SQSTM1 STIP1
Entrez ID		5264	2288
HPRD ID		03609	11794
Ensembl ID		ENSG00000107537	ENSG00000004478
Uniprot IDs		O14832	Q02790
PDB IDs		2A1X	1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY 4TW8
Enriched GO Terms of Interacting Partners?
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