PDZK1 and SLC22A5

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		PDZK1	SLC22A5
Description		PDZ domain containing 1	solute carrier family 22 member 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-containing Complex Binding	Protein Binding ATP Binding Carnitine Transmembrane Transporter Activity Symporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding Xenobiotic Transmembrane Transporter Activity
	Biological Process	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Drug Transmembrane Export	Sodium Ion Transport Response To Symbiotic Bacterium Quaternary Ammonium Group Transport Carnitine Transport Positive Regulation Of Intestinal Epithelial Structure Maintenance Sodium-dependent Organic Cation Transport Carnitine Transmembrane Transport Drug Transmembrane Export
Pathways			Carnitine metabolism Organic cation transport Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)
Drugs			L-Carnitine
Diseases			Crohn's disease Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Contrast sensitivity ( 24152035) Serum uric acid levels ( 30993211) Urate levels ( 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Acylcarnitine levels ( 26068415) Asthma ( 20860503 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Crohn's disease ( 28067908 21102463) Diastolic blood pressure ( 30578418) Fibrinogen ( 20031577) Height ( 20881960) Inflammatory bowel disease ( 28067908 23128233) Low density lipoprotein cholesterol levels ( 29083408) Mosquito bite size ( 28199695) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Serum metabolite levels ( 23093944) Ulcerative colitis ( 28067908)
Interacting Genes		29 interacting genes: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	4 interacting genes: PDZD3 PDZK1 SLC9A3R1 SLC9A3R2
Entrez ID		5174	6584
HPRD ID		04829	04539
Ensembl ID		ENSG00000174827	ENSG00000197375
Uniprot IDs		Q5T2W1	O76082
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?
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