CPSF3 and CLP1

Number of citations of the paper that reports this interaction (PubMedID 11060040)
82

Data Source:
HPRD (in vivo, in vitro)

		CPSF3	CLP1
Description		cleavage and polyadenylation specific factor 3	cleavage factor polyribonucleotide kinase subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytosol MRNA Cleavage Factor Complex
	Molecular Function	RNA Binding Endoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Metal Ion Binding	ATP Binding ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity Polydeoxyribonucleotide Kinase Activity ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Export From Nucleus MRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Processing Phosphorylation Cerebellar Cortex Development Targeting Of MRNA For Destruction Involved In RNA Interference MRNA 3'-end Processing SiRNA Loading Onto RISC Involved In RNA Interference
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Neuroticism ( 29255261) Schizophrenia ( 25056061 29483656)
Interacting Genes		6 interacting genes: CLP1 FAM107A HSPB1 PAPOLA POLR2A YWHAG	5 interacting genes: APP CPSF3 CREB3 HCFC1 NUDT21
Entrez ID		51692	10978
HPRD ID		05825	16382
Ensembl ID		ENSG00000119203	ENSG00000172409
Uniprot IDs		G5E9W3 Q9UKF6	Q92989
PDB IDs		2I7T 2I7V 6M8Q
Enriched GO Terms of Interacting Partners?
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