MBIP and RAPGEF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MBIP	RAPGEF1
Description		MAP3K12 binding inhibitory protein 1	Rap guanine nucleotide exchange factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Cytosol	Cytoplasm Early Endosome Cytosol Phagocytic Vesicle Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity SH3 Domain Binding
	Biological Process	Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Histone H3 Acetylation	Activation Of MAPKK Activity Blood Vessel Development Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Neuron Projection Development Cytokine-mediated Signaling Pathway Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Negative Regulation Of Canonical Wnt Signaling Pathway Activation Of GTPase Activity Cell-cell Adhesion Regulation Of Cell Junction Assembly Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		HATs acetylate histones	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs
Diseases
GWAS		Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335)	Cerebrospinal fluid Î±-synuclein levels ( 29959729) Optic disc size ( 31809533)
Interacting Genes		42 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SMARCB1 STX11 TGIF2LY TXLNA TXLNB VPS28 VTA1 WDR5	19 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		51562	2889
HPRD ID		14368	02627
Ensembl ID		ENSG00000151332	ENSG00000107263
Uniprot IDs		B2RCV0 Q9NS73	Q13905
PDB IDs			5L23
Enriched GO Terms of Interacting Partners?
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