RAPGEF1 and MBIP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		RAPGEF1	MBIP
Description		Rap guanine nucleotide exchange factor 1	MAP3K12 binding inhibitory protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Phagocytic Vesicle Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity SH3 Domain Binding	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Neuron Projection Development Cytokine-mediated Signaling Pathway Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Negative Regulation Of Canonical Wnt Signaling Pathway Activation Of GTPase Activity Cell-cell Adhesion Regulation Of Cell Junction Assembly Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Histone H3 Acetylation
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL	HATs acetylate histones
Drugs
Diseases
GWAS		Cerebrospinal fluid Î±-synuclein levels ( 29959729) Optic disc size ( 31809533)	Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335)
Interacting Genes		19 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1	42 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SMARCB1 STX11 TGIF2LY TXLNA TXLNB VPS28 VTA1 WDR5
Entrez ID		2889	51562
HPRD ID		02627	14368
Ensembl ID		ENSG00000107263	ENSG00000151332
Uniprot IDs		Q13905	B2RCV0 Q9NS73
PDB IDs		5L23
Enriched GO Terms of Interacting Partners?
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