NCKIPSD and ARHGEF7

Number of citations of the paper that reports this interaction (PubMedID 14559906)
9

Data Source:
HPRD (in vivo, in vitro)

		NCKIPSD	ARHGEF7
Description		NCK interacting protein with SH3 domain	Rho guanine nucleotide exchange factor 7
Image
GO Annotations	Cellular Component	Cytosol Intermediate Filament COP9 Signalosome	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Neuron Projection Neuronal Cell Body
	Molecular Function	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Cytoskeleton Organization Positive Regulation Of Neuron Projection Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Golgi Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of GTP Binding Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	EGFR downregulation NRAGE signals death through JNK Rho GTPase cycle Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Anorexia nervosa ( 31308545) Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 28892059) Ulcerative colitis ( 28067908)	Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824)
Interacting Genes		20 interacting genes: ARHGEF7 BAIAP2 DIAPH2 DIAPH3 DLG4 DMRTB1 FASLG GRB2 HSPB1 ITGB1 KHDRBS1 MAPK3 NCK1 NCK2 PSMD9 SORBS3 STAC WAS WASL YWHAG	33 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG
Entrez ID		51517	8874
HPRD ID		09450	05688
Ensembl ID		ENSG00000213672	ENSG00000102606
Uniprot IDs		Q9NZQ3	A0A024RDY9 B7Z344 B7Z6G2 E9PDQ5 Q14155 Q5W9H1
PDB IDs		6DEC 6DED 6DEE	1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?
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