UBR5 and BUB3

Number of citations of the paper that reports this interaction (PubMedID 26438829)
7

Data Source:
BioGRID (pull down)

		UBR5	BUB3
Description		ubiquitin protein ligase E3 component n-recognin 5	BUB3 mitotic checkpoint protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Binding
	Biological Process	Protein Polyubiquitination DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Gene Expression Viral Process Positive Regulation Of Protein Import Into Nucleus Progesterone Receptor Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair	Mitotic Sister Chromatid Segregation Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Chromosomal aberration frequency (total) ( 31586183) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)	Body mass index ( 28892062) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)
Interacting Genes		31 interacting genes: BARD1 BUB3 CIB1 CSPP1 DYRK2 ERG GSK3B KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 NR1I2 OTUD5 PAIP1 PAIP2 PCK1 PGR SATB1 SMAD2 SOX2 TCEA1 TOPBP1 TXNIP UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3 ZNF207	16 interacting genes: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 RPL37A SUGT1 THRA TOP1 UBA1 UBR5 WBP4
Entrez ID		51366	9184
HPRD ID		06436	04761
Ensembl ID		ENSG00000104517	ENSG00000154473
Uniprot IDs		O95071	A0A140VJF3 O43684
PDB IDs		1I2T 2QHO 3PT3
Enriched GO Terms of Interacting Partners?
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