UBR5 and PAIP1

Number of citations of the paper that reports this interaction (PubMedID 11287654)
28

Data Source:
HPRD (in vitro)

		UBR5	PAIP1
Description		ubiquitin protein ligase E3 component n-recognin 5	poly(A) binding protein interacting protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding Translation Activator Activity
	Biological Process	Protein Polyubiquitination DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Gene Expression Viral Process Positive Regulation Of Protein Import Into Nucleus Progesterone Receptor Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair	Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation MRNA Stabilization
Pathways			Deadenylation of mRNA
Drugs
Diseases
GWAS		Chromosomal aberration frequency (total) ( 31586183) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)	Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		31 interacting genes: BARD1 BUB3 CIB1 CSPP1 DYRK2 ERG GSK3B KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 NR1I2 OTUD5 PAIP1 PAIP2 PCK1 PGR SATB1 SMAD2 SOX2 TCEA1 TOPBP1 TXNIP UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3 ZNF207	6 interacting genes: EIF3A EIF3B EIF4A1 PABPC1 UBR5 WWP2
Entrez ID		51366	10605
HPRD ID		06436	05539
Ensembl ID		ENSG00000104517	ENSG00000172239
Uniprot IDs		O95071	Q9H074
PDB IDs		1I2T 2QHO 3PT3	1JH4 3NTW 3RK6
Enriched GO Terms of Interacting Partners?
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