TLR7 and MYD88

Number of citations of the paper that reports this interaction (PubMedID 16482509)
21

Data Source:
HPRD (two hybrid)

		TLR7	MYD88
Description		toll like receptor 7	MYD88 innate immune signal transduction adaptor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Phagosome Endolysosome Membrane Receptor Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Double-stranded RNA Binding Single-stranded RNA Binding Transmembrane Signaling Receptor Activity Drug Binding SiRNA Binding Pattern Recognition Receptor Activity	Death Receptor Binding Protein Binding Toll-like Receptor Binding Identical Protein Binding Protein Self-association TIR Domain Binding
	Biological Process	Microglial Cell Activation Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Inflammatory Response Defense Response To Virus Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Toll Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome	ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs		Imiquimod Hydroxychloroquine Isatoribine ANA971 Golotimod
Diseases
GWAS		Celiac disease ( 20190752)	Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		2 interacting genes: GRAMD1A MYD88	40 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 PELI2 PFKL POLR1C PRDX1 RAC1 SARM1 SIAH1 SIAH2 SMAD3 SPOP STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7
Entrez ID		51284	4615
HPRD ID		02295	03703
Ensembl ID		ENSG00000196664	ENSG00000172936
Uniprot IDs		B2R9N9 Q9NYK1	A0A0A0MS70 A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 H0Y4G9 Q99836
PDB IDs			2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N
Enriched GO Terms of Interacting Partners?
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