ZNF639 and PNKP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ZNF639	PNKP
Description		zinc finger protein 639	polynucleotide kinase 3'-phosphatase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Self-association Transcription Regulatory Region DNA Binding Metal Ion Binding	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	Positive Regulation Of Cell Growth Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleoside Monophosphate Phosphorylation Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		4 interacting genes: APTX CREBBP PNKP RIN3	17 interacting genes: APP GZMK IKZF1 KDM1A KRTAP4-12 LMNA MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		51193	11284
HPRD ID		15882	09284
Ensembl ID		ENSG00000121864	ENSG00000039650
Uniprot IDs		Q9UID6	Q96T60
PDB IDs			2BRF 2W3O
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?