PLEKHO1 and DNAJB1

Number of citations of the paper that reports this interaction (PubMedID 18624398)
14

Data Source:
BioGRID (two hybrid)

		PLEKHO1	DNAJB1
Description		pleckstrin homology domain containing O1	DnaJ heat shock protein family (Hsp40) member B1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Ruffle Membrane Muscle Cell Projection Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Binding Involved In Protein Folding Cadherin Binding Unfolded Protein Binding Chaperone Binding ATPase Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis	Response To Unfolded Protein Forebrain Development Positive Regulation Of ATPase Activity Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat
Pathways			Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Schizophrenia ( 25056061 29483656)	Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		13 interacting genes: AKT1 AKT2 C10orf88 CSNK2A1 DNAJB1 FLNB IFI35 PSMC5 RPS20 SMAD5 SMURF1 TRAF6 USP7	31 interacting genes: A2M AKT1 ANK2 APP BRCA1 BRMS1 CENPE CYP2C8 DNAJA2 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PEA15 PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TP53 ZFP36
Entrez ID		51177	3337
HPRD ID		12217	05198
Ensembl ID		ENSG00000023902	ENSG00000132002
Uniprot IDs		Q53GL0 Q5T4P9	P25685 Q6FHS4
PDB IDs		3AA1	1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR
Enriched GO Terms of Interacting Partners?
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