DNAJB1 and NQO1

Number of citations of the paper that reports this interaction (PubMedID 11821413)
11

Data Source:
HPRD (in vitro, in vivo)

		DNAJB1	NQO1
Description		DnaJ heat shock protein family (Hsp40) member B1	NAD(P)H quinone dehydrogenase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Glutamatergic Synapse	Cytoplasm Cytosol Dendrite Neuronal Cell Body Synapse
	Molecular Function	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Binding Involved In Protein Folding Cadherin Binding Unfolded Protein Binding Chaperone Binding ATPase Binding	RNA Binding NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Superoxide Dismutase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding
	Biological Process	Response To Unfolded Protein Forebrain Development Positive Regulation Of ATPase Activity Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat	Regulation Of Cellular Amino Acid Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress Synaptic Transmission, Cholinergic Aging Response To Nutrient Response To Toxic Substance Removal Of Superoxide Radicals Electron Transport Chain Response To Estradiol Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Response To Ethanol Response To Electrical Stimulus Cellular Response To Hydrogen Peroxide Cellular Response To Metal Ion Response To Nitrogen Compound Response To Hydrogen Sulfide
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling	Regulation of ornithine decarboxylase (ODC)
Drugs			Menadione Dicoumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol 5-Methoxy-1,2-Dimethyl-3-(4-Nitrophenoxymethyl)Indole-4,7-Dione Cibacron Blue Flavin adenine dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione RH-1 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE
Diseases
GWAS		Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)	Alcohol consumption (drinks per week) ( 30679032) Blood osmolality (transformed sodium) ( 28360221) Blood protein levels ( 30072576 29875488) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462) Medication use (HMG CoA reductase inhibitors) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		31 interacting genes: A2M AKT1 ANK2 APP BRCA1 BRMS1 CENPE CYP2C8 DNAJA2 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PEA15 PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TP53 ZFP36	7 interacting genes: DNAJB1 HIF1A HSPA1A ING1 STUB1 TP53 UBE2D1
Entrez ID		3337	1728
HPRD ID		05198	00518
Ensembl ID		ENSG00000132002	ENSG00000181019
Uniprot IDs		P25685 Q6FHS4	B4DLR8 P15559
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR	1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX 4CET 4CF6 5A4K 5EA2 5EAI 5FUQ 6FY4
Enriched GO Terms of Interacting Partners?
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