PCNT and RAC3

		PCNT	RAC3
Description		pericentrin	Rac family small GTPase 3
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Microtubule Membrane Centriolar Satellite	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Endomembrane System Lamellipodium Growth Cone Cytoplasmic Vesicle Filamentous Actin Cell Projection Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Calmodulin Binding Molecular Adaptor Activity	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Calcium-dependent Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Spindle Organization Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Cilium Assembly Positive Regulation Of Intracellular Protein Transport Ciliary Basal Body-plasma Membrane Docking	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Regulation Of Cell Shape Regulation Of Neuron Maturation Cerebral Cortex GABAergic Interneuron Development Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Synaptic Transmission, GABAergic Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Rho GTPase cycle PCP/CE pathway
Drugs
Diseases		Microcephalic osteodysplastic primordial dwarfism, type II (MOPD II) Seckel syndrome
GWAS		Heel bone mineral density ( 30598549) Pre-treatment viral load in HIV-1 infection ( 31219150) Treatment resistant depression ( 30468137)
Interacting Genes		21 interacting genes: AKAP9 CALM1 CALM2 CCP110 CDK12 CEP55 COL6A1 DISC1 HPRT1 NDUFV3 PCM1 PDE9A PFKL PKNOX1 RAC3 S100B SH3BGR TP53BP1 TUBG1 TUBGCP2 TUBGCP3	9 interacting genes: ANKRD11 AR ARHGDIA ARHGDIB CIB1 ESR1 HNF1A NRBP1 PCNT
Entrez ID		5116	5881
HPRD ID		05804	03629
Ensembl ID		ENSG00000160299	ENSG00000169750
Uniprot IDs		O95613	P60763
PDB IDs			2C2H 2G0N 2IC5 2OV2 2QME
Enriched GO Terms of Interacting Partners?
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