TXNDC11 and HSP90B1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		TXNDC11	HSP90B1
Description		thioredoxin domain containing 11	heat shock protein 90 beta family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Cell Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Protein Binding	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Cell Redox Homeostasis	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Protein Transport Cytokine-mediated Signaling Pathway Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Sequestering Of Calcium Ion Cellular Response To ATP
Pathways			Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin 1-Methoxy-2-(2-Methoxyethoxy)Ethane N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS		Plasma renin activity levels ( 29650764) Rheumatoid arthritis ( 30423114 24390342) Weight ( 28552196)	Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		17 interacting genes: ACAA1 ATXN7 CDKN1A DUOX1 DUOX2 GFI1B HSP90B1 KRT15 KRT18 NOS3 ORC5 RACGAP1 RPS19 RPS6KA5 SOCS3 STAT5A TPO	28 interacting genes: APOB ASGR1 BIRC2 CACYBP CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 ESR1 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 OS9 POLR2E PTPN11 SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11
Entrez ID		51061	7184
HPRD ID		07125	01860
Ensembl ID		ENSG00000153066	ENSG00000166598
Uniprot IDs		Q6PKC3	P14625 V9HWP2
PDB IDs			4NH9
Enriched GO Terms of Interacting Partners?
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