FIS1 and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
7

Data Source:
BioGRID (two hybrid)

		FIS1	VKORC1
Description		fission, mitochondrial 1	vitamin K epoxide reductase complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Cell Mitochondrion Mitochondrial Outer Membrane Peroxisome Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Mitochondrial Outer Membrane Protein-containing Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Mitochondrial Fission Autophagy Of Mitochondrion Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Response To Muscle Activity Peroxisome Fission Response To Nutrient Levels Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Cellular Response To Glucose Stimulus Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Cellular Response To Toxic Substance Cellular Response To Peptide Response To Fluoride Cellular Response To Thapsigargin Response To Flavonoid Response To Hypobaric Hypoxia Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Blood Coagulation Response To Organonitrogen Compound Response To Organic Cyclic Compound Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Vitamin K Metabolic Process Response To Antibiotic Oxidation-reduction Process Bone Development
Pathways		Class I peroxisomal membrane protein import	Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases			Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Rheumatoid arthritis ( 30891314)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		11 interacting genes: A2M BCAP31 CREB3 DNM1L KASH5 MARCHF5 NOS3 PEX5 TBC1D15 UBC VKORC1	83 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CREB3 CXADR DCTPP1 DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		51024	79001
HPRD ID		12352	10540
Ensembl ID		ENSG00000214253	ENSG00000167397
Uniprot IDs		Q9Y3D6	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		1NZN 1PC2
Enriched GO Terms of Interacting Partners?
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