FIS1 and PEX5

Number of citations of the paper that reports this interaction (PubMedID 20178365)
16

Data Source:
BioGRID (unspecified method)

		FIS1	PEX5
Description		fission, mitochondrial 1	peroxisomal biogenesis factor 5
Image
GO Annotations	Cellular Component	Cell Mitochondrion Mitochondrial Outer Membrane Peroxisome Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Mitochondrial Outer Membrane Protein-containing Complex	Cytoplasm Peroxisome Peroxisomal Membrane Golgi Apparatus Cytosol Membrane Protein-containing Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein N-terminus Binding
	Biological Process	Mitochondrial Fission Autophagy Of Mitochondrion Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Apoptotic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Response To Muscle Activity Peroxisome Fission Response To Nutrient Levels Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Cellular Response To Glucose Stimulus Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Cellular Response To Toxic Substance Cellular Response To Peptide Response To Fluoride Cellular Response To Thapsigargin Response To Flavonoid Response To Hypobaric Hypoxia Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Protein Import Into Peroxisome Membrane
Pathways		Class I peroxisomal membrane protein import	Pexophagy
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Rheumatoid arthritis ( 30891314)	IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917)
Interacting Genes		11 interacting genes: A2M BCAP31 CREB3 DNM1L KASH5 MARCHF5 NOS3 PEX5 TBC1D15 UBC VKORC1	71 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 FIS1 GDPD5 GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 RPL14 S100A6 SCARB1 SCP2 SIRT3 SLC27A2 SNUPN SSTR5 TINF2 TM6SF1 TOMM7 USP2 USP9X ZNF772
Entrez ID		51024	5830
HPRD ID		12352	02684
Ensembl ID		ENSG00000214253	ENSG00000139197
Uniprot IDs		Q9Y3D6	A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542
PDB IDs		1NZN 1PC2	1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO
Enriched GO Terms of Interacting Partners?
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