FOXP3 and PRR20A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		FOXP3	PRR20A
Description		forkhead box P3	proline rich 20A
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Homeostasis Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment T Cell Mediated Immunity Tolerance Induction To Self Antigen Regulation Of T Cell Anergy Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction Chromatin Remodeling Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Histone Acetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Cytokine Biosynthetic Process T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cytokine Secretion Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Negative Regulation Of T-helper 17 Cell Differentiation
Pathways		RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates transcription of genes involved in WNT signaling
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) Permanent neonatal diabetes mellitus (PNDM)
GWAS		Vitiligo ( 27723757)	Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Systolic blood pressure ( 30224653)
Interacting Genes		10 interacting genes: EP300 IKZF4 KAT8 NFAT5 NFATC2 NLK PRR20A RBPMS RUNX1 STUB1	26 interacting genes: ATXN1 BANP C1orf94 DAB1 DAZAP2 FAM168A FOXP3 GATA2 NAA38 NCK2 NEDD9 PITX1 POGZ RBFOX1 RBM10 RBPMS ROR2 SELENOV SIAH1 SOX5 SP4 THAP1 TOLLIP VAC14 ZC3H10 ZNF488
Entrez ID		50943	122183
HPRD ID		02242	13445
Ensembl ID		ENSG00000049768	ENSG00000204919
Uniprot IDs		B7ZLG1 Q9BZS1	P86478 P86479 P86480 P86481 P86496
PDB IDs		3QRF 4WK8
Enriched GO Terms of Interacting Partners?
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