PRR20A and GATA2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PRR20A	GATA2
Description		proline rich 20A	GATA binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component		Cell Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function		RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Cell Fate Determination Neuron Migration Embryonic Placenta Development Transcription, DNA-templated Phagocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Primitive Erythrocyte Differentiation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Response To Lipid Somatic Stem Cell Population Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Positive Regulation Of Mast Cell Degranulation Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Positive Regulation Of Phagocytosis, Engulfment Definitive Hemopoiesis Semicircular Canal Development Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cochlea Development GABAergic Neuron Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Forebrain Neuron Differentiation
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Systolic blood pressure ( 30224653)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) Eosinophil counts ( 19198610) Lymphocyte percentage of white cells ( 27863252) Neutrophil percentage of white cells ( 27863252) Preterm birth (maternal effect) ( 28877031) Prostate cancer ( 31562322) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878) White blood cell count ( 21738480) White blood cell count (basophil) ( 28158719) White blood cell count (eosinophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		26 interacting genes: ATXN1 BANP C1orf94 DAB1 DAZAP2 FAM168A FOXP3 GATA2 NAA38 NCK2 NEDD9 PITX1 POGZ RBFOX1 RBM10 RBPMS ROR2 SELENOV SIAH1 SOX5 SP4 THAP1 TOLLIP VAC14 ZC3H10 ZNF488	36 interacting genes: ADAMTSL4 AKT1 CDK1 CEBPA EP300 FBXW7 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 LMO2 MAPK1 MDFI NOTCH2NLA PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1
Entrez ID		122183	2624
HPRD ID		13445	00673
Ensembl ID		ENSG00000204919	ENSG00000179348
Uniprot IDs		P86478 P86479 P86480 P86481 P86496	P23769
PDB IDs			5O9B
Enriched GO Terms of Interacting Partners?
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