ATP5F1C and NGEF

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATP5F1C	NGEF
Description		ATP synthase F1 subunit gamma	neuronal guanine nucleotide exchange factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Core F(1) Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix Membrane	Cytosol Membrane Growth Cone
	Molecular Function	RNA Binding ATPase Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Oxidative Phosphorylation ATP Biosynthetic Process ATP Synthesis Coupled Proton Transport Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Dendritic Spine Morphogenesis
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation	NRAGE signals death through JNK Rho GTPase cycle EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events
Drugs		Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B PICEATANNOL N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Contrast sensitivity ( 24152035) Heel bone mineral density ( 30598549 28869591) Pursuit maintenance gain ( 29064472) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Sudden cardiac arrest ( 30169657) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		25 interacting genes: APP ATP5F1A ATP5F1B CA12 CCND3 CCT7 CHMP2B DPP3 EGFR ELOF1 FBXO7 GDPD2 ITIH2 MED15 MPP1 NDUFB3 NGEF PAWR PJA1 PNO1 POLA2 PTEN PTN SERPINA1 ZNF337	10 interacting genes: ATP5F1C C7orf25 C8orf33 EPHA4 FAM118B HCK MRPL44 NUDT21 SH2D1A TAF1D
Entrez ID		509	25791
HPRD ID		00156	10442
Ensembl ID		ENSG00000165629	ENSG00000066248
Uniprot IDs		B4DL14 P36542 Q8TAS0	B4DDI2 Q8N5V2
PDB IDs
Enriched GO Terms of Interacting Partners?
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