RNF141 and TRIM8

Number of citations of the paper that reports this interaction (PubMedID 22493164)
5

Data Source:
BioGRID (two hybrid)

		RNF141	TRIM8
Description		ring finger protein 141	tripartite motif containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Membrane	Cytosol PML Body
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Protein Autoubiquitination	Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Viral Release From Host Cell
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Feeling nervous ( 29500382) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Schizophrenia ( 25056061 30285260) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: DTX3 MAP3K1 SMURF1 TRIM24 TRIM8	46 interacting genes: BRAP CBL CCNH ITSN1 MAGEC2 MKRN3 MSL2 OTUB2 PCGF5 RAD18 RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UHRF2 USP2 USP21 USP39 USP7 XIAP
Entrez ID		50862	81603
HPRD ID		11509	06934
Ensembl ID		ENSG00000110315	ENSG00000171206
Uniprot IDs		Q8WVD5	Q9BZR9
PDB IDs		2ECN 5XEK
Enriched GO Terms of Interacting Partners?
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