TRIM8 and RNF138

Number of citations of the paper that reports this interaction (PubMedID 22493164)
5

Data Source:
BioGRID (two hybrid)

		TRIM8	RNF138
Description		tripartite motif containing 8	ring finger protein 138
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol PML Body	Nucleus Site Of Double-strand Break
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity	Single-stranded DNA Binding Protein Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Viral Release From Host Cell	Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Wnt Signaling Pathway Protein Ubiquitination Cellular Response To Leukemia Inhibitory Factor
Pathways		Interferon gamma signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Feeling nervous ( 29500382) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Schizophrenia ( 25056061 30285260) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		46 interacting genes: BRAP CBL CCNH ITSN1 MAGEC2 MKRN3 MSL2 OTUB2 PCGF5 RAD18 RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UHRF2 USP2 USP21 USP39 USP7 XIAP	12 interacting genes: APP CFAP206 LNX2 PCBP4 QKI RAD51D TAF9 TCF7L2 TRIM8 UBE2D2 UBE2D4 UBE2W
Entrez ID		81603	51444
HPRD ID		06934	11508
Ensembl ID		ENSG00000171206	ENSG00000134758
Uniprot IDs		Q9BZR9	A0A140VJT9 Q8WVD3
PDB IDs
Enriched GO Terms of Interacting Partners?
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