PAX3 and WWTR1

Number of citations of the paper that reports this interaction (PubMedID 16300735)
38

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PAX3	WWTR1
Description		paired box 3	WW domain containing transcription regulator 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Body
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Muscle Organ Development Sensory Perception Of Sound Animal Organ Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		HATs acetylate histones	Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases		Alveolar rhabdomyosarcoma Craniofacial-deafness-hand syndrome Waardenburg syndrome (WS)
GWAS		Adolescent idiopathic scoliosis ( 26394188) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Diisocyanate-induced asthma ( 25918132) Facial morphology ( 31763980 22341974) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Information processing speed ( 25869804) Male-pattern baldness ( 28196072) middle facial morphology traits (quantitative measurement) ( 27193062) Monobrow ( 27182965) Monobrow thickness ( 26926045) Nose size ( 27182965) Vitamin D levels ( 25208829)	Height ( 31562340) Preeclampsia ( 23551011)
Interacting Genes		16 interacting genes: CIB1 DAXX FZR1 HDAC10 IPO13 MEOX1 MEOX2 MITF MSX1 POU3F2 RAD23B SOX10 SOX8 TAF1 TBP WWTR1	17 interacting genes: DAPK1 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PLOD2 PPP1CA RUNX1 SLC9A3R2 SUMO3 TEAD3 TEAD4 WBP2 YWHAE YWHAG YWHAZ
Entrez ID		5077	25937
HPRD ID		09421	09580
Ensembl ID		ENSG00000135903	ENSG00000018408
Uniprot IDs		P23760	Q9GZV5
PDB IDs		3CMY	5N5R 5N5T 5N5W 5N75
Enriched GO Terms of Interacting Partners?
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