DELEC1 and ARNTL

Number of citations of the paper that reports this interaction (PubMedID 23555304)
16

Data Source:
BioGRID (two hybrid)

		DELEC1	ARNTL
Description		deleted in esophageal cancer 1	aryl hydrocarbon receptor nuclear translocator like
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex PML Body Chromatoid Body Intracellular Membrane-bounded Organelle
	Molecular Function		Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Aryl Hydrocarbon Receptor Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding Repressing Transcription Factor Binding E-box Binding
	Biological Process	Negative Regulation Of Cell Proliferation	Regulation Of Transcription, DNA-templated Protein Import Into Nucleus Spermatogenesis Circadian Rhythm Negative Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Hair Cycle Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Regulation Of Insulin Secretion Regulation Of Cell Cycle Response To Redox State Maternal Process Involved In Parturition Positive Regulation Of Canonical Wnt Signaling Pathway Oxidative Stress-induced Premature Senescence Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Acetylation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Cellular Senescence Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways			BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression Circadian Clock
Drugs
Diseases
GWAS			Body mass index ( 25673413) C-reactive protein levels ( 30388399) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronotype ( 30696823) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878 27618448 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Face memory ( 31596458) Feeling guilty ( 29500382) Feeling miserable ( 29500382) General risk tolerance (MTAG) ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Iron status biomarkers (transferrin levels) ( 25352340) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean arterial pressure ( 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 31589552) Neurociticism ( 29500382) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Psoriasis ( 30921485) Schizophrenia ( 23358160) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Tea consumption ( 31046077) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		30 interacting genes: ARNTL BHLHE41 CIPC CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B EZH2 FBXL15 FKBP15 GSK3B NFIL3 NONO NPAS2 NR1D2 PER1 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E RORB RORC	21 interacting genes: AHR BHLHE40 CLOCK CRY1 CSNK1E DELEC1 EP300 EPAS1 HIF1A HLF HSP90AA1 KAT2B NPAS2 NPAS4 PER3 RARA RHOA RHOU RXRA SIRT1 UBE2I
Entrez ID		50514	406
HPRD ID		16068	03973
Ensembl ID		ENSG00000173077	ENSG00000133794
Uniprot IDs			A0A140VKD3 B2RCL8 O00327
PDB IDs			4H10
Enriched GO Terms of Interacting Partners?
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