PAFAH1B2 and PINX1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PAFAH1B2	PINX1
Description		platelet activating factor acetylhydrolase 1b catalytic subunit 2	PIN2 (TERF1) interacting telomerase inhibitor 1
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Extracellular Region Nucleolus Cytoplasm Cytosol Plasma Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Cell Nucleoplasm Nucleolus Spindle
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Platelet-activating Factor Acetyltransferase Activity	Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding
	Biological Process	Lipid Metabolic Process Spermatogenesis Brain Development Lipid Catabolic Process Positive Regulation Of Macroautophagy Neutrophil Degranulation	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomeric DNA Binding Positive Regulation Of Protein Localization To Nucleolus
Pathways		Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Blood protein levels ( 28240269 23696881) HDL cholesterol ( 24507774) Protein quantitative trait loci ( 18464913) Systolic blood pressure ( 30578418)	Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder ( 30804558) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte counts ( 27863252) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Retinal vascular caliber ( 21060863) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899) Triglycerides ( 24097068 30275531 20686565) Type 2 diabetes ( 30054458) White blood cell count ( 27863252)
Interacting Genes		16 interacting genes: ACIN1 ASF1A CCT3 CRK PAFAH1B1 PAFAH1B3 PINX1 PPP1R12C PRKN REXO1 RPLP0 SLA SNUPN STAT3 TIMM50 ZFP36L1	10 interacting genes: AIDA APP CACYBP GABPA MCRS1 MPZ PAFAH1B2 TERF1 TERT TP63
Entrez ID		5049	54984
HPRD ID		03940	05934
Ensembl ID		ENSG00000168092	ENSG00000254093
Uniprot IDs		P68402 V9HW44	Q96BK5
PDB IDs		1VYH
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?