PAFAH1B2 and PAFAH1B1

Number of citations of the paper that reports this interaction (PubMedID 10727864)
7

Data Source:
HPRD (in vitro, two hybrid)

		PAFAH1B2	PAFAH1B1
Description		platelet activating factor acetylhydrolase 1b catalytic subunit 2	platelet activating factor acetylhydrolase 1b regulatory subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Extracellular Region Nucleolus Cytoplasm Cytosol Plasma Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Astral Microtubule Kinetochore Cell Nuclear Envelope Centrosome Cytosol Kinesin Complex Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex Cell Leading Edge Motile Cilium Nuclear Membrane Stereocilium Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Central Region Of Growth Cone Axon Cytoplasm
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Platelet-activating Factor Acetyltransferase Activity	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Dynein Intermediate Chain Binding Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding
	Biological Process	Lipid Metabolic Process Spermatogenesis Brain Development Lipid Catabolic Process Positive Regulation Of Macroautophagy Neutrophil Degranulation	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Microtubule-based Process Nuclear Migration Chemical Synaptic Transmission Germ Cell Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Protein Secretion Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Osteoclast Development Positive Regulation Of Embryonic Development Establishment Of Planar Polarity Of Embryonic Epithelium Regulation Of GTPase Activity Cortical Microtubule Organization Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Microtubule Sliding Nuclear Envelope Disassembly Establishment Of Centrosome Localization Maintenance Of Centrosome Location Auditory Receptor Cell Development Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cochlea Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Ciliary Basal Body-plasma Membrane Docking Regulation Of Microtubule Motor Activity
Pathways		Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Blood protein levels ( 28240269 23696881) HDL cholesterol ( 24507774) Protein quantitative trait loci ( 18464913) Systolic blood pressure ( 30578418)	Adverse response to drug ( 30420678) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)
Interacting Genes		16 interacting genes: ACIN1 ASF1A CCT3 CRK PAFAH1B1 PAFAH1B3 PINX1 PPP1R12C PRKN REXO1 RPLP0 SLA SNUPN STAT3 TIMM50 ZFP36L1	22 interacting genes: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DNAI1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A
Entrez ID		5049	5048
HPRD ID		03940	03329
Ensembl ID		ENSG00000168092	ENSG00000007168
Uniprot IDs		P68402 V9HW44	P43034
PDB IDs		1VYH
Enriched GO Terms of Interacting Partners?
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