ORM2 and STK3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ORM2	STK3
Description		orosomucoid 2	serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Azurophil Granule Lumen Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function		Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Platelet Degranulation Regulation Of Immune System Process Acute-phase Response Neutrophil Degranulation Positive Regulation Of Interleukin-1 Secretion Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Tumor Necrosis Factor Secretion	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Regulation Of Mitotic Cell Cycle Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Platelet degranulation Neutrophil degranulation	Signaling by Hippo
Drugs		Disopyramide Lidocaine Methadone Imipramine Chlorpromazine Oxycodone Thalidomide Zinc
Diseases
GWAS		Blood protein levels ( 29875488)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		3 interacting genes: CYP39A1 PRDX6 STK3	34 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF1 SAV1 SLMAP STK4 SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		5005	6788
HPRD ID		00725	05433
Ensembl ID		ENSG00000228278	ENSG00000104375
Uniprot IDs		P19652	A0A087WZ06 A0A384MR07 Q13188
PDB IDs		3APU 3APV 3APW 3APX	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2
Enriched GO Terms of Interacting Partners?
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