OPRK1 and GNA15

Number of citations of the paper that reports this interaction (PubMedID 9572309)
11

Data Source:
HPRD (in vivo)

		OPRK1	GNA15
Description		opioid receptor kappa 1	G protein subunit alpha 15
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection Synapse	Cell Heterotrimeric G-protein Complex Plasma Membrane Synapse
	Molecular Function	G Protein-coupled Receptor Activity Opioid Receptor Activity Protein Binding Dynorphin Receptor Activity Peptide Binding Neuropeptide Binding	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception Locomotory Behavior Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Opioid Receptor Signaling Pathway Regulation Of Saliva Secretion Defense Response To Virus	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates neuronal receptors and channels	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Progesterone Pethidine Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Menthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine Ketamine 3-Methylthiofentanyl Heroin Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Asimadoline CR665 ADL 10-0101 Mianserin Tapentadol Nalmefene Alvimopan Ketobemidone Methylnaltrexone Eluxadoline Propoxyphene napsylate Naldemedine
Diseases
GWAS		IgE levels in asthmatics (D.p. specific) ( 23967269) Modic changes ( 30808802)	Glucose homeostasis traits ( 25524916) Heart failure ( 20445134)
Interacting Genes		5 interacting genes: GABARAPL1 GNA15 GPRASP1 OPRD1 SLC9A3R1	19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1
Entrez ID		4986	2769
HPRD ID		01309	00760
Ensembl ID		ENSG00000082556	ENSG00000060558
Uniprot IDs		A0A5F9ZI09 P41145	P30679
PDB IDs		2A0D 2IQN 4DJH 6B73
Enriched GO Terms of Interacting Partners?
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