OPRD1 and OPRK1

Number of citations of the paper that reports this interaction (PubMedID 11069979)
153

Data Source:
HPRD (in vivo)

		OPRD1	OPRK1
Description		opioid receptor delta 1	opioid receptor kappa 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Intrinsic Component Of Plasma Membrane Dendrite Membrane Neuron Projection Axon Terminus Membrane Raft Spine Apparatus Neuronal Dense Core Vesicle Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection Synapse
	Molecular Function	G Protein-coupled Receptor Activity Opioid Receptor Activity Protein Binding Receptor Serine/threonine Kinase Binding Enkephalin Receptor Activity Peptide Binding Neuropeptide Binding	G Protein-coupled Receptor Activity Opioid Receptor Activity Protein Binding Dynorphin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Immune Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Adult Locomotory Behavior Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Complex Assembly Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Opioid Receptor Signaling Pathway Eating Behavior Regulation Of Mitochondrial Membrane Potential Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Response To Toxic Substance	Immune Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception Locomotory Behavior Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Opioid Receptor Signaling Pathway Regulation Of Saliva Secretion Defense Response To Virus
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling	Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates neuronal receptors and channels
Drugs		Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Naltrexone Sufentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Ketamine 3-Methylthiofentanyl Dimethylthiambutene Heroin Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl ADL5859 Tapentadol Nalmefene Alvimopan Ketobemidone Eluxadoline Propoxyphene napsylate Naldemedine	Tramadol Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Progesterone Pethidine Oxycodone Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Menthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine Ketamine 3-Methylthiofentanyl Heroin Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Asimadoline CR665 ADL 10-0101 Mianserin Tapentadol Nalmefene Alvimopan Ketobemidone Methylnaltrexone Eluxadoline Propoxyphene napsylate Naldemedine
Diseases
GWAS		Tourette syndrome ( 30818990)	IgE levels in asthmatics (D.p. specific) ( 23967269) Modic changes ( 30808802)
Interacting Genes		16 interacting genes: ADRB2 ARRB1 ARRB2 GNA15 GNAI1 GNAI2 GNAO1 GNAZ GPRASP1 GRK2 KLHL3 OPRK1 OPRM1 PRKCA PRKCD PRKCE	5 interacting genes: GABARAPL1 GNA15 GPRASP1 OPRD1 SLC9A3R1
Entrez ID		4985	4986
HPRD ID		01308	01309
Ensembl ID		ENSG00000116329	ENSG00000082556
Uniprot IDs		P41143	A0A5F9ZI09 P41145
PDB IDs		1OZC 2IQM 4N6H 4RWA 4RWD	2A0D 2IQN 4DJH 6B73
Enriched GO Terms of Interacting Partners?
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